| U8 | Raw Unsigned 8-Bit Audio Data |
| U96 | EasyZip Temporary File |
| UAP | User Agent Wireless Telephony Profile |
| UB | Raw Unsigned Byte (8-bit) Data |
| UC2 | Ultra-Compressor II Archive |
| UCM | Urban Chaos Game File |
| UCN | Ultra-Compressor II Archive |
| UDB | Win2000 Uniqueness Database File |
| UDC | Acrobat Spelling File |
| UDF | Windows NT Uniqueness Database File |
| UDF | Photostyler Image Filter |
| UDF | MS Excel User Defined Function |
| UDL | MS Data Link |
| UDW | Raw Unsigned DoubleWord (32-bit) Data |
| UE2 | Ultra-Compressor II Encrypted Archive |
| UFO | Ulead Object File |
| UG | Drawing File (various) |
| UHA | UHARC Compressed Archive |
| UHS | Universal Hint System File |
| UI | User Interface |
| UI | Geoworks UI Compiler Espire Source |
| UIF | WordPerfect Long Prompts |
| UIH | Geoworks UI Compiler Espire Header |
| UL | uLAW Audio File |
| ULD | Procomm Uploaded Files |
| ULS | User Location Service |
| ULT | Ultratracker Music Module |
| UMB | MemMaker Backup Archive |
| UNI | Forecast-Pro Data |
| UNI | MikMod UniMod Formatted File |
| UNX | Text File (usually UNIX) |
| UOL | PhotoImpact Object Library File |
| UPD | Updated Program Data (various) |
| UPD | Universal Print Driver (cross-platform) |
| UPD | dBase Update File |
| UPI | ULead Photo Impact Program File |
| UPJ | ULead Project File |
| UPO | dBase Compiled Update File |
| UPX | ULead Photo Express Saved Image File |
| URF | Radar ViewPoint Universal Radar Format |
| URL | Internet Shortcut |
| USB | D-Link FM Radio Update |
| USB | USB Protocol Analyzer Trace |
| USE | MKS Source Integrity File |
| USL | LaserJet Landscape Font |
| USP | LaserJet Portrait Font |
| USP | PageMaker Printer Font |
| USR | User Database (various) |
| UTF | AOL Updating Files |
| UTL | Sound File |
| UTP | BinPatch Patch Data File |
| UU | Compressed Archive File (UUENCODE) |
| UUD | UU-decoded file |
| UUE | UU-encoded file |
| UW | Raw Unsigned Word (16-bit) Data |
| UW | Unitype GlobalWriter File |
| UW | Audio File |
| UWF | UltraTracker Wave File |
| UWL | WordPerfect User Word List |